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Metagenome sequencing

 

Source: TH

 Context: The pandemic led to the development of rapid and unbiased genome sequencing techniques for pathogen surveillance. The metagenomic approach, used to directly sequence patient samples without prior knowledge of the infectious agent, quickly identified SARS-CoV-2 as the cause of COVID-19.

  • This genomic approach, termed metagenomics, has revolutionized pathogen identification and surveillance. The widespread adoption of genome sequencing techniques birthed numerous technologies, including the CovidSeq assay, which facilitated national and international genome surveillance efforts.

 Genome sequencing has also been employed to track avian influenza, a prime candidate for genomic surveillance due to its potential for rapid spread and impact on both animals and humans.

  

What is Metagenome sequencing?

Metagenome sequencing is a technique that directly analyzes genetic material from samples without prior knowledge of the organisms present. It’s used to identify and study the entire genetic diversity of microbial communities, enabling the detection of known and unknown pathogens in a high-throughput manner.