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CSIR-IICT Nuclear Magnetic Resonance test facility

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CSIR-IICT Nuclear Magnetic Resonance test facility

What to study?

For Prelims: What is NMR spectroscopy?

For Mains: Significance of NMR.

 

Context: The CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad has announced that the Nuclear Magnetic Resonance (NMR) test facility at the institute has passed the US Food and Drug Administration (USFDA) inspection with “no observations”.

 

Background:

The USFDA inspected the NMR facility during August 21-22 and found the facility in an acceptable state of compliance with regard to Current Good Manufacturing Practice (CGMP). Accordingly, it classified the facility as “no action initiated (NAI)”.

 

What is NMR?

The NMR spectroscopy is an important technique for structural characterization of pharmaceutical and other chemical molecules.

The technique is used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure.

 

How it works?

  1. The sample is placed in a magnetic field and the NMR signal is produced by excitation of the nuclei sample with radio waves into nuclear magnetic resonance, which is detected with sensitive radio receivers.
  2. The intramolecular magnetic field around an atom in a molecule changes the resonance frequency, thus giving access to details of the electronic structure of a molecule and its individual functional groups.
  3. As the fields are unique or highly characteristic to individual compounds, in modern organic chemistry practice, NMR spectroscopy is the definitive method to identify monomolecular organic compounds.

 

Sources: the Hindu.